THE HIGH AFFINITY PERIPHERAL BENZODIAZEPINE RECEPTOR LIGAND DAA1106 BINDS TO ACTIVATED AND INFECTED BRAIN MACROPHAGES IN AREAS OF SYNAPTIC DEGENERATION: IMPLICATIONS FOR PET IMAGING OF NEUROINFLAMMATION IN LENTIVIRAL ENCEPHALITIS

The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds to activated and infected brain macrophages in areas of synaptic degeneration: Implications for PET imaging of neuroinflammation in lentiviral encephalitis

HIV encephalitis (HIVE) is characterized by neurodegeneration mediated by toxins derived from infected and activated brain macrophages.Since the peripheral benzodiazepine SHARP SJ-SF197E00X-EN Integrated Tall Freezer receptor (PBR) is abundant on brain macrophages, we hypothesized that [3H]DAA1106, a new PBR ligand, can label infected and activated

read more

Macrophages: The Good, the Bad, and the Gluttony

Macrophages are dynamic cells that play critical roles in the induction and resolution of sterile inflammation.In this review, we will compile and interpret recent findings on the plasticity of macrophages and how these cells contribute to the development of non-infectious inflammatory diseases, with a particular focus on allergic and autoimmune di

read more


Juvenile ossifying fibroma: Psammamatoid variant

Juvenile ossifying fibroma is a rare fibro-osseous lesion containing variable amount Demi Tasse Spoons of calcified masses, which resembles bone or cementum within a fibrocellular connective tissue stroma.It has variable clinical behavior, highly aggressive in nature including invasion and destruction of adjacent anatomic structures ASCORBIC ACID w

read more